Colonoscopy W/Lesion Removal: What It Costs and What's Fair

CPT 45385  · Medicare rate: $223  · National avg charge: $3,241  · BillKarma data from 101 providers

Reviewed 2026-04-04  · Pricing data year: 2026

Colonoscopy W/Lesion Removal (CPT 45385) is a surgical procedure typically performed in a hospital or accredited outpatient surgical center. It is usually recommended after more conservative treatments—such as medication or physical therapy—have not resolved the underlying problem. Recovery time ranges from a few days to several weeks depending on patient health and procedure complexity.

Cost by Billing Grade

Grade Avg Hospital Charge Medicare Rate Est. Patient Cost* Hospitals
C $1,300 $223 $260 24
D $1,049 $223 $210 3
F $3,763 $223 $753 56
N/A $4,572 $223 $914 18

*Estimated patient cost assumes 20% coinsurance after deductible is met. Actual cost depends on your specific plan, deductible status, and network.

Cost Range Across Hospitals

Min: $448 Max: $9,245
Medicare: $223 Avg: $3,241
Grade A (≤2x Medicare) Grade B (2–3x) Grade C (3–5x) Grade D/F (5x+)

What This Procedure Typically Costs by Facility Type

Hospital
101 providers
$448 $9,245 | Avg: $3,241 (14.5x Medicare)

Find Providers Near You for This Procedure

Showing 10 lowest-markup providers nationally across hospitals, surgery centers, and imaging centers. Enter ZIP code to compare local providers side by side.

Provider Type Location Grade Charge Benchmark Markup
AdventHealth East Orlando Hospital Orlando, FL D $448 $223
Medicare OPPS
2.0x
ASCENSION CALUMET HOSPITAL Hospital CHILTON, WI C $778 $223
Medicare OPPS
3.5x
Avera St. Luke’s Hospital Hospital ABERDEEN, SD N/A $810 $223
Medicare OPPS
3.6x
ASCENSION PROVIDENCE ROCHESTER HOSPITAL Hospital ROCHESTER, MI F $903 $223
Medicare OPPS
4.0x
BEN TAUB GENERAL HOSPITAL Hospital HOUSTON, TX N/A $1,017 $223
Medicare OPPS
4.6x
Eastern Maine Medical Center Hospital Bangor, ME C $1,049 $223
Medicare OPPS
4.7x
Eastern Maine Healthcare Systems Inland Hospital Hospital Waterville, ME C $1,188 $223
Medicare OPPS
5.3x
ASCENSION MEDICAL GROUP ST. VINCENT Hospital NORTH VERNON, IN C $1,197 $223
Medicare OPPS
5.4x
ADVENTHEALTH LAKE WALES Hospital LAKE WALES, FL C $1,350 $223
Medicare OPPS
6.0x
ADVENTIST HEALTH SYSTEM/SUNBELT, INC. Hospital TAMPA, FL C $1,350 $223
Medicare OPPS
6.0x

What Is a Fair Price for This Procedure?

Medicare pays $223 for Colonoscopy W/Lesion Removal (CPT 45385). This rate is set by CMS based on the actual cost of delivering the procedure, including physician time, overhead, and equipment. It's the most reliable national benchmark for what the procedure is worth.

A hospital charging $447 (2x Medicare) or less earns an A billing grade — these are the most fairly priced facilities for this procedure. The national average charge is $3,241 (14.5x Medicare).

If your bill shows more than $670 (3x Medicare) for this procedure, it may be worth reviewing the charges carefully. Upload your bill to check →

Frequently Asked Questions

How much does Colonoscopy W/Lesion Removal cost with insurance?
With insurance, your out-of-pocket cost for Colonoscopy W/Lesion Removal (CPT 45385) depends on your deductible, coinsurance rate, and in-network status. Medicare pays $223 for this procedure; the national average hospital charge is $3,241. Under standard 20% coinsurance after deductible, a patient at an average-charging hospital would owe approximately $648. Always verify your benefits before scheduling.
Does where I have Colonoscopy W/Lesion Removal done affect my recovery?
Hospital quality and surgical volume can influence outcomes for procedures like Colonoscopy W/Lesion Removal. High-volume centers tend to have lower complication rates for complex surgeries. However, billing grade is separate from quality ratings—some highly graded billing hospitals also have strong clinical outcomes. Review both the BillKarma billing grade and CMS quality stars when choosing a facility.
How do I negotiate the cost of Colonoscopy W/Lesion Removal if I'm on a high-deductible plan?
If you're paying a significant portion out-of-pocket, ask the hospital for their cash price before scheduling. Many hospitals offer 10–40% discounts for self-pay patients. Medicare pays $223 for this procedure—use that as your negotiating anchor. Also ask the billing department about payment plans or charity care if the cost poses a financial hardship.

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